Novel Insulin Sensitivity Index Derived from Oral Glucose Tolerance Test
نویسندگان
چکیده
منابع مشابه
Clamp-like Index: a Novel, Highly Sensitive Insulin Sensitivity Index to Calculate Hyperinsulinemic Clamp Glucose Infusion Rates from Oral Glucose Tolerance Test in Nondiabetic Humans
Objective. Insulin resistance (IR), the underlying pathophysiological mechanism of the metabolic syndrome, could predict not only type-2 diabetes (T2DM) development, but also cardiovascular disease. Thus, precise IR measurement in individuals at risk for metabolic diseases would support clinical risk stratification. However, the “gold-standard” to measure IR, the hyperinsulinemic clamp-test, is...
متن کاملComparison of oral glucose insulin sensitivity with other insulin sensitivity surrogates from oral glucose tolerance tests in Chinese.
INTRODUCTION There is no single method of measuring insulin resistance that is both accurate and can be easily performed by general researchers. We validate the accuracy of oral glucose insulin sensitivity (OGIS) in the Chinese by comparing the OGIS120 and OGIS180, homeostasis model assessment of insulin resistance (HOMA-IR), and quantitative insulin sensitivity check index (OUICKI) with steady...
متن کاملA model-based method for assessing insulin sensitivity from the oral glucose tolerance test.
OBJECTIVE Available insulin sensitivity (IS) methods based on the oral glucose tolerance test (OGTT) are empirical. We used a glucose-insulin model to derive an OGTT-based IS (oral glucose insulin sensitivity [OGIS]) index, which predicts glucose clearance in a glucose clamp. We validated OGIS against clamp data. RESEARCH DESIGN AND METHODS OGIS requires glucose and insulin concentrations fro...
متن کاملMuscle and liver insulin resistance indexes derived from the oral glucose tolerance test.
OBJECTIVE To derive indexes for muscle and hepatic insulin sensitivity from the measurement of plasma glucose and insulin concentrations during an oral glucose tolerance test (OGTT). RESEARCH DESIGN AND METHODS A total of 155 subjects of Mexican-American origin (58 male and 97 female, aged 18-70 years, BMI 20-65 kg/m(2)) with normal glucose tolerance (n = 100) or impaired glucose tolerance (n...
متن کاملInsulin secretion and insulin sensitivity on the oral glucose tolerance test (OGTT) in middle-aged Japanese.
The aim of this study was to assess the changes in insulin secretion and insulin sensitivity in relation to fasting and 2-hour plasma glucose (PG) levels and to assess the independent contributions of their impairments to non-diabetic hyperglycemia. A total of 2157 Japanese workers (mean age 52.6±7.3 years and mean BMI 23.9±3.2 kg/m(2)) underwent an oral glucose tolerance test (OGTT). Of thes...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2003
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2002-021127